Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic mapping in Diversity Outbred mice identifies a Trpa1 variant influencing late-phase formalin response

27 Mar 2019

Abstract excerpt

Identification of genetic variants that influence susceptibility to pain is key to identifying molecular mechanisms and targets for effective and safe therapeutic alternatives to opioids. To identify genes and variants associated with persistent pain, we measured late-phase response to formalin injection in 275 male and female Diversity Outbred mice genotyped for over 70,000 single nucleotide polymorphisms. One...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ion channel regulation and function
Share to Ion Channels and Receptors
Share to Pain Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31335644
DOI: 10.1097/j.pain.0000000000001571

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic mapping in Diversity Outbred mice identifies a Trpa1 variant influencing late-phase formalin responsePMID 31335644Read ↗

Genetic mapping in Diversity Outbred mice identifies a <i>Trpa1</i> variant influencing late phase formalin responseSemantic proximity Read ↗

The beta3 subunit of the Na+,K+-ATPase mediates variable nociceptive sensitivity in the formalin test.Semantic proximity Read ↗

Precise genetic mapping and integrative bioinformatics in Diversity Outbred mice reveals Hydin as a novel pain gene.Semantic proximity Read ↗

Screening for pain phenotypes: analysis of three congenic mouse strains on a battery of nine nociceptive assays.Semantic proximity Read ↗

Atp1a2 and Kcnj9 are candidate genes underlying sensitivity to oxycodone-induced locomotor activation and withdrawal-induced anxiety-like behaviors in C57BL/6 substrainsSemantic proximity Read ↗

Pain genes.Semantic proximity Read ↗

Genetic architecture of human pain perception.Semantic proximity Read ↗

The Yin and Yang of pain: variability in formalin test nociception and morphine analgesia produced by the Yin Yang 1 transcription factor gene.Semantic proximity Read ↗

A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene.Semantic proximity Read ↗

Genomic methods for clinical and translational pain research.Semantic proximity Read ↗

A systematic review of genome-wide association studies for pain, nociception, neuropathy, and pain treatment responses.Semantic proximity Read ↗

Chronic pain and genetic background interact and influence opioid analgesia, tolerance, and physical dependence.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.