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Article

An expression signature of phenotypic resistance to hepatocellular carcinoma identified by cross-species gene expression analysis.

Cellular oncology (Dordrecht, Netherlands) - 1 Jun 2012

Frau Maddalena, Simile Maria M, Tomasi Maria L, Demartis Maria I, Daino Lucia, Seddaiu Maria A, Brozzetti Stefania, Feo Claudio F, Massarelli Giovanni, Solinas Giuliana, Feo Francesco, Lee Ju-Seog, Pascale Rosa M

Abstract excerpt

BACKGROUND AND AIMS: Hepatocarcinogenesis is under polygenic control. We analyzed gene expression patterns of dysplastic liver nodules (DNs) and hepatocellular carcinomas (HCCs) chemically-induced in F344 and BN rats, respectively susceptible and resistant to hepatocarcinogenesis. METHODS: Expression profiles were performed by microarray and validated by quantitative RT-PCR and Western blot. RESULTS: Cluster...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22434528
DOI: 10.1007/s13402-011-0067-z
PMCID: PMC4517440

Genes

BHMT
DUSP1
DMBT1
GNMT
MYC
PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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