Article
Genotype-phenotype relationships in hepatocellular tumors from mice and man.
Hepatology (Baltimore, Md.) - 1 Aug 2005
Stahl Sabine, Ittrich Carina, Marx-Stoelting Philip, Köhle Christoph, Altug-Teber Ozge, Riess Olaf, Bonin Michael, Jobst Jürgen, Kaiser Stephan, Buchmann Albrecht, Schwarz Michael
Abstract excerpt
Experimentally induced liver tumors in mice harbor activating mutations in either Catnb (beta-catenin) or Ha-ras, according to the carcinogenic treatment. We have now investigated by microarray analysis the gene expression profiles in tumors of the two genotypes. In total, 364 genes or expressed sequences with aberrant expression relative to normal liver were identified, but only 30 of these demonstrated...
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