Article
Mybl2 expression is under genetic control and contributes to determine a hepatocellular carcinoma susceptible phenotype.
Journal of hepatology - 1 Jul 2011
Frau Maddalena, Ladu Sara, Calvisi Diego F, Simile Maria M, Bonelli Piero, Daino Lucia, Tomasi Maria L, Seddaiu Maria A, Feo Francesco, Pascale Rosa M
Abstract excerpt
BACKGROUND & AIMS: MYBL2 is implicated in human malignancies and over expressed in hepatocellular carcinoma (HCC). We investigated Mybl2 role in the acquisition of susceptibility to HCC and tumor progression. METHODS: MYBL2 mRNA and protein levels were evaluated by quantitative RT-PCR and immunoblotting, respectively. MYBL2 expression in HCC cell lines was controlled through MYBL2 cDNA or anti-MYBL2 siRNA...
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