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Article

Hepatocellular carcinoma as a complex polygenic disease. Interpretive analysis of recent developments on genetic predisposition.

Biochimica et biophysica acta - 1 Apr 2006

Feo F, De Miglio M R, Simile M M, Muroni M R, Calvisi D F, Frau M, Pascale R M

Abstract excerpt

The different frequency of hepatocellular carcinoma (HCC) in humans at risk suggests a polygenic predisposition. However, detection of genetic variants is difficult in genetically heterogeneous human population. Studies on mouse and rat models identified 7 hepatocarcinogenesis susceptibility (Hcs) and 2 resistance (Hcr) loci in mice, and 7 Hcs and 9 Hcr loci in rats, controlling multiplicity and size of...

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Share to Carcinoma, Hepatocellular
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Endoplasmic Reticulum Stress and Disease

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Source

Identifiers

PMID: 16216419
DOI: 10.1016/j.bbcan.2005.08.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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