Article

Identifying TCDD-resistance genes via murine and rat comparative genomics and transcriptomics

2019-04-08

Abstract excerpt

The aryl hydrocarbon receptor (AHR) mediates many of the toxic effects of 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD). However, the AHR alone is insufficient to explain the widely different outcomes among organisms. Attempts to identify unknown factor(s) have been confounded by genetic variability of model organisms. Here, we evaluated three transgenic mouse lines, each expressing a different rat AHR isoform (rW...

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Literature Corpus work: cec9d527-b009-55ea-b230-71ab0c620a19
DOI: 10.1101/602698

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