Article
Forkhead box M1B is a determinant of rat susceptibility to hepatocarcinogenesis and sustains ERK activity in human HCC.
Gut - 1 May 2009
Calvisi D F, Pinna F, Ladu S, Pellegrino R, Simile M M, Frau M, De Miglio M R, Tomasi M L, Sanna V, Muroni M R, Feo F, Pascale R M
Abstract excerpt
BACKGROUND AND AIMS: Previous studies indicate unrestrained cell cycle progression in liver lesions from hepatocarcinogenesis-susceptible Fisher 344 (F344) rats and a block of G(1)-S transition in corresponding lesions from resistant Brown Norway (BN) rats. Here, the role of the Forkhead box M1B (FOXM1) gene during hepatocarcinogenesis in both rat models and human hepatocellular carcinoma (HCC) was assessed....
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