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Article

A novel patch assembly domain in Num1 mediates dynein anchoring at the cortex during spindle positioning.

The Journal of cell biology - 19 Mar 2012

Tang Xianying, Germain Bryan St, Lee Wei-Lih

Abstract excerpt

During mitosis in budding yeast, cortically anchored dynein generates pulling forces on astral microtubules to position the mitotic spindle across the mother-bud neck. The attachment molecule Num1 is required for dynein anchoring at the cell membrane, but how Num1 assembles into stationary cortical patches and interacts with dynein is unknown. We show that an N-terminal Bin/Amphiphysin/Rvs (BAR)-like domain in...

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Identifiers

PMID: 22431751
DOI: 10.1083/jcb.201112017
PMCID: PMC3308694

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A novel patch assembly domain in Num1 mediates dynein anchoring at the cortex during spindle positioning.PMID 22431751Read ↗

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Pac1/LIS1 promotes an uninhibited conformation of dynein that coordinates its localization and activitySemantic proximity Read ↗

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Optogenetic reconstitution reveals that Dynein-Dynactin-NuMA clusters generate cortical spindle-pulling forces as a multi-arm ensembleSemantic proximity Read ↗

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