Article
The cortical protein Num1p is essential for dynein-dependent interactions of microtubules with the cortex.
The Journal of cell biology - 11 Dec 2000
Heil-Chapdelaine R A, Oberle J R, Cooper J A
Abstract excerpt
In budding yeast, the mitotic spindle moves into the neck between the mother and bud via dynein-dependent sliding of cytoplasmic microtubules along the cortex of the bud. How dynein and microtubules interact with the cortex is unknown. We found that cells lacking Num1p failed to exhibit dynein-dependent microtubule sliding in the bud, resulting in defective mitotic spindle movement and nuclear segregation. Num1p...
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