Article
A non-ring-like form of the Dam1 complex modulates microtubule dynamics in fission yeast.
Proceedings of the National Academy of Sciences of the United States of America - 27 Jul 2010
Gao Qi, Courtheoux Thibault, Gachet Yannick, Tournier Sylvie, He Xiangwei
Abstract excerpt
The Dam1 complex is a kinetochore component that couples chromosomes to the dynamic ends of kinetochore microtubules (kMTs). Work in the budding yeast Saccharomyces cerevisiae has shown that the Dam1 complex forms a 16-unit ring encircling and tracking the tip of a MT in vitro, consistent with its cellular function as a coupler. Dam1 also forms smaller, nonring patches in vitro that track the dynamic ends of MTs....
Topics
- Chromosome Segregation
- Cytoplasm
- Gene Dosage
- Green Fluorescent Proteins
- Kinetics
- Kinetochores
- Microscopy, Fluorescence
- Microtubule-Associated Proteins
- Microtubules
- Mitosis
- Mutation
- Polymers
- Protein Binding
- Schizosaccharomyces