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Article

Huntingtin with an expanded polyglutamine repeat affects the Jab1-p27(Kip1) pathway.

Neurobiology of disease - 1 Jun 2012

Cong S Y, Pepers B A, Zhou T T, Kerkdijk H, Roos R A, van Ommen G J, Dorsman J C

Abstract excerpt

Expansion of polyglutamine repeats is the cause of at least nine inherited human neurodegenerative disorders, including Huntington's disease (HD). It is widely accepted that deregulation of the transcriptional coactivator CBP by expanded huntingtin (htt) plays an important role in HD molecular pathogenesis. In this study, we report on a novel target of expanded polyglutamine stretches, the transcriptional...

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Identifiers

PMID: 22426400
DOI: 10.1016/j.nbd.2012.03.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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