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Article

Suppression of aggregate formation of mutant huntingtin potentiates CREB-binding protein sequestration and apoptotic cell death.

Molecular and cellular neurosciences - 1 Feb 2012

Choi Yong-Joon, Kim Song-In, Lee Jae-Won, Kwon Yong-Soo, Lee Hee Jae, Kim Sung-Soo, Chun Wanjoo

Abstract excerpt

Although aggregates of mutant huntingtin are a pathological hallmark of Huntington's disease (HD), the role of inclusions in the pathogenesis remains inconclusive. Sequestration of CBP into mutant huntingtin has been reported to play a significant role in the pathogenesis of HD. However, whether aggregate formation of mutant huntingtin is necessary for the sequestration of CBP is not fully elucidated. In the...

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PMID: 22122824
DOI: 10.1016/j.mcn.2011.11.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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