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Article

Aberrant histone acetylation, altered transcription, and retinal degeneration in a Drosophila model of polyglutamine disease are rescued by CREB-binding protein.

Genes & development - 15 Jun 2003

Taylor J Paul, Taye Addis A, Campbell Catherine, Kazemi-Esfarjani Parsa, Fischbeck Kenneth H, Min Kyung-Tai

Abstract excerpt

Sequestration of the transcriptional coactivator CREB-binding protein (CBP), a histone acetyltransferase, has been implicated in the pathogenesis of polyglutamine expansion neurodegenerative disease. We used a Drosophila model to demonstrate that polyglutamine-induced neurodegeneration is accompanied by a defect in histone acetylation and a substantial alteration in the transcription profile. Furthermore, we...

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Identifiers

PMID: 12815067
DOI: 10.1101/gad.1087503
PMCID: PMC196076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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