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Mutant huntingtin represses CBP, but not p300, by binding and protein degradation.

Molecular and cellular neurosciences - 1 Dec 2005

Cong Shu-Yan, Pepers Barry A, Evert Bernd O, Rubinsztein David C, Roos Raymund A C, van Ommen Gert-Jan B, Dorsman Josephine C

Abstract excerpt

Huntington's disease can be used as a model to study neurodegenerative disorders caused by aggregation-prone proteins. It has been proposed that the entrapment of transcription factors in aggregates plays an important role in pathogenesis. We now report that the transcriptional activity of CBP is already repressed in the early time points by soluble mutant huntingtin, whereas the histone acetylase activity of...

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PMID: 16456924

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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