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Article

Enhanced autophagic cell death in expanded polyhistidine variants of HOXA1 reduces PBX1-coupled transcriptional activity and inhibits neuronal differentiation.

Journal of neuroscience research - 15 Feb 2007

Paraguison Rubigilda C, Higaki Katsumi, Yamamoto Kenji, Matsumoto Hideo, Sasaki Tsukasa, Kato Nobumasa, Nanba Eiji

Abstract excerpt

HOXA1 is a member of the homeobox gene family and is involved in early brain development. In our previous study, we identified novel variants of polyhistidine repeat tract in HOXA1 gene and showed that ectopic expression of expanded variants led to enhanced intranuclear aggregation and accelerated cell death in a time-dependent manner. Here, we further investigate the implications of polyhistidine variants on...

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Source

Identifiers

PMID: 17131398
DOI: 10.1002/jnr.21137

Genes

HOXA1
PBX1
HOXB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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