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Article

CREB-binding protein modulates repeat instability in a Drosophila model for polyQ disease.

Science (New York, N.Y.) - 30 Mar 2007

Jung Joonil, Bonini Nancy

Abstract excerpt

Although expansion of trinucleotide repeats accounts for over 30 human diseases, mechanisms of repeat instability remain poorly understood. We show that a Drosophila model for the CAG/polyglutamine (polyQ) disease spinocerebellar ataxia type 3 recapitulates key features of human CAG-repeat instability, including large repeat changes and strong expansion bias. Instability is dramatically enhanced by transcription...

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Source

Identifiers

PMID: 17332375
DOI: 10.1126/science.1139517

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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