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Article

CHIP suppresses polyglutamine aggregation and toxicity in vitro and in vivo.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 5 Oct 2005

Miller Victor M, Nelson Rick F, Gouvion Cynthia M, Williams Aislinn, Rodriguez-Lebron Edgardo, Harper Scott Q, Davidson Beverly L, Rebagliati Michael R, Paulson Henry L

Abstract excerpt

Huntington's disease (HD) and other polyglutamine (polyQ) neurodegenerative diseases are characterized by neuronal accumulation of the disease protein, suggesting that the cellular ability to handle abnormal proteins is compromised. As both a cochaperone and ubiquitin ligase, the C-terminal Hsp70 (heat shock protein 70)-interacting protein (CHIP) links the two major arms of protein quality control, molecular...

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Identifiers

PMID: 16207874
DOI: 10.1523/JNEUROSCI.3001-05.2005
PMCID: PMC6725774

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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