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Article

Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity.

Science (New York, N.Y.) - 23 Mar 2001

Nucifora F C, Sasaki M, Peters M F, Huang H, Cooper J K, Yamada M, Takahashi H, Tsuji S, Troncoso J, Dawson V L, Dawson T M, Ross C A

Abstract excerpt

Expanded polyglutamine repeats have been proposed to cause neuronal degeneration in Huntington's disease (HD) and related disorders, through abnormal interactions with other proteins containing short polyglutamine tracts such as the transcriptional coactivator CREB binding protein, CBP. We found...

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Source

Identifiers

PMID: 11264541
DOI: 10.1126/science.1056784

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11264541-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity.PMID 11264541Read ↗

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