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Siah-1-interacting protein regulates mutated huntingtin protein aggregation in Huntington’s disease models

19 Mar 2022

Abstract excerpt

BACKGROUND: Huntington's disease (HD) is a neurodegenerative disorder whereby mutated huntingtin protein (mHTT) aggregates when polyglutamine repeats in the N-terminal of mHTT exceeds 36 glutamines (Q). However, the mechanism of this pathology is unknown. Siah1-interacting protein (SIP) acts as an adaptor protein in the ubiquitination complex and mediates degradation of other proteins. We hypothesized that mHTT...

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PMID: 35305696
DOI: 10.1186/s13578-022-00755-0

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