Article
Mutant HSPB1 causes loss of translational repression by binding to PCBP1, an RNA binding protein with a possible role in neurodegenerative disease.
Acta neuropathologica communications - 11 Jan 2017
Geuens Thomas, De Winter Vicky, Rajan Nicholas, Achsel Tilmann, Mateiu Ligia, Almeida-Souza Leonardo, Asselbergh Bob, Bouhy Delphine, Auer-Grumbach Michaela, Bagni Claudia, Timmerman Vincent
Abstract excerpt
The small heat shock protein HSPB1 (Hsp27) is an ubiquitously expressed molecular chaperone able to regulate various cellular functions like actin dynamics, oxidative stress regulation and anti-apoptosis. So far disease causing mutations in HSPB1 have been associated with neurodegenerative diseases such as distal hereditary motor neuropathy, Charcot-Marie-Tooth disease and amyotrophic lateral sclerosis. Most...
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