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Article

Perturbation of sodium channel structure by an inherited Long QT Syndrome mutation.

Nature communications - 28 Feb 2012

Glaaser Ian W, Osteen Jeremiah D, Puckerin Akil, Sampson Kevin J, Jin Xiangshu, Kass Robert S

Abstract excerpt

The cardiac voltage-gated sodium channel (Na(V)1.5) underlies impulse conduction in the heart, and its depolarization-induced inactivation is essential in control of the duration of the QT interval of the electrocardiogram. Perturbation of Na(V)1.5 inactivation by drugs or inherited mutation can underlie and trigger cardiac arrhythmias. The carboxy terminus has an important role in channel inactivation, but...

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Source

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Identifiers

PMID: 22426227
DOI: 10.1038/ncomms1717
PMCID: PMC3518026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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