Article

Structural basis for pore blockade of the human cardiac sodium channel Na <sub>v</sub> 1.5 by tetrodotoxin and quinidine

2019-12-30

Abstract excerpt

Among the nine subtypes of human voltage-gated Na + (Na v ) channels, tetrodotoxin (TTX)-resistant Na v 1.5 is the primary one in heart. More than 400 point mutations have been identified in Na v 1.5 that are associated with cardiac disorders exemplified by type 3 long QT syndrome and Brugada syndrome, making Na v 1.5 a common target for class I antiarrythmic drugs. Here we present the cryo-EM structures of N...

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Literature Corpus work: cee9e4e6-0994-5d8e-8912-e26044fdb8ba
DOI: 10.1101/2019.12.30.890681

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Structural basis for pore blockade of the human cardiac sodium channel Na <sub>v</sub> 1.5 by tetrodotoxin and quinidineDOI 10.1101/2019.12.30.890681Read

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