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Article

Clinical characterization of type 1 long QT syndrome caused by C-terminus Kv7.1 variants.

Heart rhythm - 1 Jul 2024

Kashiwa Asami, Itoh Hideki, Makiyama Takeru, Wada Yuko, Ozawa Junichi, Kato Koichi, Fukuyama Megumi, Nakajima Tadashi, Ohno Seiko, Horie Minoru

Abstract excerpt

BACKGROUND: Variants in the KCNQ1 gene, encoding the α-subunit of the slow component of delayed rectifier K+ channel Kv7.1, cause long QT syndrome (LQTS) type 1. The location of variants may be one of the factors in determining prognosis. However, detailed genotype-phenotype relationships associated with C-terminus variants remain unelucidated. OBJECTIVE: We investigated the clinical characteristics and...

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PMID: 38367891
DOI: 10.1016/j.hrthm.2024.02.021

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