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Article

Tryptophan scanning of D1S6 and D4S6 C-termini in voltage-gated sodium channels.

Biophysical journal - 1 Aug 2003

Wang Sho-Ya, Bonner Kaitlin, Russell Corinna, Wang Ging Kuo

Abstract excerpt

Recent reports suggest that four S6 C-termini may jointly close the voltage-gated cation channel at the cytoplasmic side, probably as an inverted teepee structure. In this study we substituted individually a total of 18 residues at D1S6 and D4S6 C-terminal ends of the rNav1.4 Na(+) channel alpha-subunit with tryptophan (W) and examined their corresponding gating properties when expressed in Hek293t cells along...

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Identifiers

PMID: 12885638
DOI: 10.1016/S0006-3495(03)74530-5
PMCID: PMC1303212

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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