Article

Voltage Sensor Conformations Induced by LQTS-associated Mutations in hERG Potassium Channels

2024-05-18

Abstract excerpt

<h4>ABSTRACT</h4> Voltage sensors are essential for electromechanical coupling in hERG K + channels, critical to cardiac rhythm. These sensors respond to membrane potential changes by moving within the transmembrane electric field. Mutations in hERG voltage-sensing arginines, associated with Long-QT syndrome, alter channel gating, though underlying mechanisms remain unclear. Using live-cell fluorescence lifetime...

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Literature Corpus work: 902d641b-0cd9-51fc-87a5-621b994551ae
DOI: 10.1101/2024.05.17.594747

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