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Article

DISC1 variants 37W and 607F disrupt its nuclear targeting and regulatory role in ATF4-mediated transcription.

Human molecular genetics - 15 Jun 2012

Malavasi Elise L V, Ogawa Fumiaki, Porteous David J, Millar J Kirsty

Abstract excerpt

Disrupted-In-Schizophrenia 1 (DISC1), a strong genetic candidate for psychiatric illness, encodes a multicompartmentalized molecular scaffold that regulates interacting proteins with key roles in neurodevelopment and plasticity. Missense DISC1 variants are associated with the risk of mental illness and with brain abnormalities in healthy carriers, but the underlying mechanisms are unclear. We examined the effect...

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Source

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Identifiers

PMID: 22422769
DOI: 10.1093/hmg/dds106
PMCID: PMC3363331

Genes

DISC1
ATF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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