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Article

Disrupted in schizophrenia 1 and phosphodiesterase 4B: towards an understanding of psychiatric illness.

The Journal of physiology - 15 Oct 2007

Millar J Kirsty, Mackie Shaun, Clapcote Steven J, Murdoch Hannah, Pickard Ben S, Christie Sheila, Muir Walter J, Blackwood Douglas H, Roder John C, Houslay Miles D, Porteous David J

Abstract excerpt

Disrupted in schizophrenia 1 (DISC1) is one of the most convincing genetic risk factors for major mental illness identified to date. DISC1 interacts directly with phosphodiesterase 4B (PDE4B), an independently identified risk factor for schizophrenia. DISC1-PDE4B complexes are therefore likely to be involved in molecular mechanisms underlying psychiatric illness. PDE4B hydrolyses cAMP and DISC1 may regulate cAMP...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17823207
DOI: 10.1113/jphysiol.2007.140210
PMCID: PMC2277141

Genes

DISC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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