Article
Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts.
American journal of medical genetics. Part A - 1 Apr 2012
Shi Min, Murray Jeffrey C, Marazita Mary L, Munger Ronald G, Ruczinski Ingo, Hetmanski Jacqueline B, Wu Tao, Murray Tanda, Redett Richard J, Wilcox Allen J, Lie Rolv T, Jabs Ethylin Wang, Wu-Chou Yah Huei, Chen Philip K, Wang Hong, Ye Xiaoqian, Yeow Vincent, Chong Samuel S, Shi Bing, Christensen Kaare, Scott Alan F, Patel Poorav, Cheah Felicia, Beaty Terri H
Abstract excerpt
We performed a genome wide association analysis of maternally-mediated genetic effects and parent-of-origin (POO) effects on risk of orofacial clefting (OC) using over 2,000 case-parent triads collected through an international cleft consortium. We used log-linear regression models to test individual SNPs. For SNPs with a P-value <10(-5) for maternal genotypic effects, we also applied a haplotype-based method,...
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