Article
Genome-wide analysis of parent-of-origin interaction effects with environmental exposure (PoOxE): An application to European and Asian cleft palate trios.
PloS one - 1 Jan 2017
Haaland Øystein A, Jugessur Astanand, Gjerdevik Miriam, Romanowska Julia, Shi Min, Beaty Terri H, Marazita Mary L, Murray Jeffrey C, Wilcox Allen J, Lie Rolv T, Gjessing Håkon K
Abstract excerpt
Cleft palate only is a common birth defect with high heritability. Only a small fraction of this heritability is explained by the genetic variants identified so far, underscoring the need to investigate other disease mechanisms, such as gene-environment (GxE) interactions and parent-of-origin (PoO) effects. Furthermore, PoO effects may vary across exposure levels (PoOxE effects). Such variation is the focus of...
Topics
- Alcohol Drinking
- Asian People
- Avitaminosis
- Carrier Proteins
- Cleft Palate
- Female
- Gene-Environment Interaction
- Genome-Wide Association Study
- Glutamate Carboxypeptidase II