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Article

Genetic Interactions in Nonsyndromic Orofacial Clefts in Europe-EUROCRAN Study.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association - 1 Nov 2017

Mossey Peter A, Little Julian, Steegers-Theunissen Regine, Molloy Anne, Peterlin Borut, Shaw William C, Johnson Candice, FitzPatrick David R, Franceschelli Paola, Rubini Michele

Abstract excerpt

BACKGROUND: Nonsyndromic cleft lip with or without cleft palate (nsCL±P) and nonsyndromic cleft palate (nsCP) are caused by a combination of genetic and environmental risk factors. We investigated gene-environment and gene-gene joint effects in a large multicenter study of case-parent triads. METHODS: The nsCL±P or nsCP triads were recruited in 11 European countries between 2001 and 2005. We collected DNA samples...

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Source

Identifiers

PMID: 27996298
DOI: 10.1597/16-037

Genes

MSX1
MTHFR
TGFA
MTHFD1
SATB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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