Article
Genome-Wide Scan for Parent-of-Origin Effects in a sub-Saharan African Cohort With Nonsyndromic Cleft Lip and/or Cleft Palate (CL/P).
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association - 1 Jul 2022
Gowans Lord J J, Comnick Carissa L, Mossey Peter A, Eshete Mekonen A, Adeyemo Wasiu L, Naicker Thirona, Awotoye Waheed A, Petrin Aline, Adeleke Chinyere, Donkor Peter, Busch Tamara D, James Olutayo, Ogunlewe Mobolanle O, Li Mary, Olotu Joy, Hassan Mohaned, Adeniyan Oluwole A, Obiri-Yeboah Solomon, Arthur Fareed K N, Agbenorku Pius, Oti Alexander A, Olatosi Olubukola, Adamson Olawale O, Fashina Azeez A, Zeng Erliang, Marazita Mary L, Adeyemo Adebowale A, Murray Jeffrey C, Butali Azeez
Abstract excerpt
OBJECTIVE: Nonsyndromic cleft lip and/or cleft palate (NSCL/P) have multifactorial etiology where genetic factors, gene-environment interactions, stochastic factors, gene-gene interactions, and parent-of-origin effects (POEs) play cardinal roles. POEs arise when the parental origin of alleles differentially impacts the phenotype of the offspring. The aim of this study was to identify POEs that can increase risk...
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