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Genetic factors influencing risk to orofacial clefts: today’s challenges and tomorrow’s opportunities

30 Nov 2016

Abstract excerpt

Orofacial clefts include cleft lip (CL), cleft palate (CP), and cleft lip and palate (CLP), which combined represent the largest group of craniofacial malformations in humans with an overall prevalence of one per 1,000 live births. Each of these birth defects shows strong familial aggregation, suggesting a major genetic component to their etiology. Genetic studies of orofacial clefts extend back centuries, but it...

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PMID: 27990279
DOI: 10.12688/f1000research.9503.1

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