Article
Genome-wide analysis of parent-of-origin effects in non-syndromic orofacial clefts.
European journal of human genetics : EJHG - 1 Jun 2014
Garg Paras, Ludwig Kerstin U, Böhmer Anne C, Rubini Michele, Steegers-Theunissen Regine, Mossey Peter A, Mangold Elisabeth, Sharp Andrew J
Abstract excerpt
Parent-of-origin (PofO) effects, such as imprinting are a phenomenon where the effect of variants depends on parental origin. Conventional association studies assume that phenotypic effects are independent of parental origin, and are thus severely underpowered to detect such non-Mendelian effects. Risk of orofacial clefts is influenced by genetic and environmental effects, the latter including maternal-specific...
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