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Article

Assessing the impact of adherence to anti-retroviral therapy on treatment failure and resistance evolution in HIV.

Journal of the Royal Society, Interface - 7 Sept 2012

Cadosch Dominique, Bonhoeffer Sebastian, Kouyos Roger

Abstract excerpt

The adherence of patients to therapy is a crucial factor for successful HIV anti-retroviral therapy. Imperfect adherence may lead to treatment failure, which can cause the emergence of resistance within viral populations. We have developed a stochastic model that incorporates compartments of latently infected cells and virus genotypes with different susceptibilities to three simultaneously used drugs. With this...

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Share to Antiretroviral Therapy, Highly Active
Share to Drug Resistance, Multiple, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to HIV Infections

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Share to Models, Biological

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Source

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Identifiers

PMID: 22417909
DOI: 10.1098/rsif.2012.0127
PMCID: PMC3405760

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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