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Article

Pre-existence and emergence of drug resistance in a generalized model of intra-host viral dynamics.

Epidemics - 1 Dec 2012

Alexander Helen K, Bonhoeffer Sebastian

Abstract excerpt

Understanding the source of drug resistance emerging within a treated patient is an important problem, from both clinical and basic evolutionary perspectives. Resistant mutants may arise de novo either before or after treatment is initiated, with different implications for prevention. Here we inv...

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PMID: 23351371
DOI: 10.1016/j.epidem.2012.10.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23351371-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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