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Article

Antiretroviral dynamics determines HIV evolution and predicts therapy outcome.

Nature medicine - 1 Sept 2012

Rosenbloom Daniel I S, Hill Alison L, Rabi S Alireza, Siliciano Robert F, Nowak Martin A

Abstract excerpt

Despite the high inhibition of viral replication achieved by current anti-HIV drugs, many patients fail treatment, often with emergence of drug-resistant virus. Clinical observations show that the relationship between adherence and likelihood of resistance differs dramatically among drug classes. We developed a mathematical model that explains these observations and predicts treatment outcomes. Our model...

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Share to Anti-Retroviral Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22941277
DOI: 10.1038/nm.2892
PMCID: PMC3490032

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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