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Article

Modeling the HIV Protease Inhibitor Adherence–Resistance Curve by Use of Empirically Derived Estimates

11 Jun 2004

Abstract excerpt

The standard view postulates a bell-shaped relationship between adherence to therapy and development of drug-resistant human immunodeficiency virus (HIV), with a resistance peak at a moderate level of adherence. This relationship has not been confirmed empirically. We statistically modeled the relationship between adherence and development of drug resistance, using empirically defined relationships of the rate of...

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PMID: 15195256
DOI: 10.1086/420790

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