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Article

Adherence and drug resistance: predictions for therapy outcome

22 Apr 2000

Abstract excerpt

We combine standard pharmacokinetics with an established model of viral replication to predict the outcome of therapy as a function of adherence to the drug regimen. We consider two types of treatment failure: failure to eliminate the wild-type virus, and the emergence of drug-resistant virus. Specifically, we determine the conditions under which resistance dominates as a result of imperfect adherence. We derive...

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PMID: 10819155
DOI: 10.1098/rspb.2000.1079

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