Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Resistance to protease inhibitors in a model of HIV-1 infection with impulsive drug effects.

Bulletin of mathematical biology - 1 Jan 2014

Miron Rachelle E, Smith Robert J

Abstract excerpt

BACKGROUND: The emergence of drug resistance is one of the most prevalent reasons for treatment failure in HIV therapy. This has severe implications for the cost of treatment, survival and quality of life. METHODS: We use mathematical modelling to describe the interaction between T cells, HIV-1 and protease inhibitors. We use impulsive differential equations to examine the effects of different levels of protease...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4-Positive T-Lymphocytes
Share to Computer Simulation
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Viral

Share to HIV Infections

Share to HIV Protease Inhibitors

Share to Lymphocyte Count

Share to Mathematical Concepts

Source

Identifiers

PMID: 24194434
DOI: 10.1007/s11538-013-9903-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Resistance to protease inhibitors in a model of HIV-1 infection with impulsive drug effects.PMID 24194434Read ↗

Antiretroviral dynamics determines HIV evolution and predicts therapy outcome.Semantic proximity Read ↗

Mathematical analysis of antiretroviral therapy aimed at HIV-1 eradication or maintenance of low viral loads.Semantic proximity Read ↗

Assessing the impact of adherence to anti-retroviral therapy on treatment failure and resistance evolution in HIV.Semantic proximity Read ↗

Mathematical approaches in the study of viral kinetics and drug resistance in HIV-1 infection.Semantic proximity Read ↗

Optimal Antiviral Switching to Minimize Resistance Risk in HIV TherapySemantic proximity Read ↗

HIV-1 polymerase inhibition by nucleoside analogs: cellular- and kinetic parameters of efficacy, susceptibility and resistance selection.Semantic proximity Read ↗

Dynamic multidrug therapies for HIV: a control theoretic approach.Semantic proximity Read ↗

Adherence and drug resistance: predictions for therapy outcomeSemantic proximity Read ↗

Stochastic modelling of genotypic drug-resistance for human immunodeficiency virus towards long-term combination therapy optimization.Semantic proximity Read ↗

Modeling HIV dynamics and antiviral response with consideration of time-varying drug exposures, adherence and phenotypic sensitivity.Semantic proximity Read ↗

Combating Susceptibility to Drug ResistanceLessons from HIV-1 ProteaseSemantic proximity Read ↗

A Darwinian model for the evolution of drug resistance to long-acting PrEP during an early HIV infection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.