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Article

A Mathematical Model to Predict HIV Virological Failure and Elucidate the Role of Lymph Node Drug Penetration.

CPT: pharmacometrics & systems pharmacology - 1 Jul 2017

Sanche S, Sheehan N, Mesplède T, Wainberg M A, Li J, Nekka F

Abstract excerpt

Preventing virological failure following HIV treatment remains a difficult task that is further complicated by the emergence of drug resistance. We have developed a mathematical model able to explain and predict HIV virological outcomes for various compounds and patients' drug intake patterns. Compared to current approaches, this model considers, altogether, drug penetration into lymph nodes, a refined adherence...

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Identifiers

PMID: 28556627
DOI: 10.1002/psp4.12200
PMCID: PMC5706346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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