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Article

Understanding patterns of HIV multi-drug resistance through models of temporal and spatial drug heterogeneity.

eLife - 2 Sept 2021

Feder Alison F, Harper Kristin N, Brumme Chanson J, Pennings Pleuni S

Abstract excerpt

Triple-drug therapies have transformed HIV from a fatal condition to a chronic one. These therapies should prevent HIV drug resistance evolution, because one or more drugs suppress any partially resistant viruses. In practice, such therapies drastically reduced, but did not eliminate, resistance evolution. In this article, we reanalyze published data from an evolutionary perspective and demonstrate several...

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Share to Anti-HIV Agents
Share to Drug Resistance, Multiple, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Selection, Genetic

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Identifiers

PMID: 34473060
DOI: 10.7554/eLife.69032
PMCID: PMC8412921

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