Article
Repression of germline RNAi pathways in somatic cells by retinoblastoma pathway chromatin complexes.
PLoS genetics - 1 Jan 2012
Wu Xiaoyun, Shi Zhen, Cui Mingxue, Han Min, Ruvkun Gary
Abstract excerpt
The retinoblastoma (Rb) tumor suppressor acts with a number of chromatin cofactors in a wide range of species to suppress cell proliferation. The Caenorhabditis elegans retinoblastoma gene and many of these cofactors, called synMuv B genes, were identified in genetic screens for cell lineage defects caused by growth factor misexpression. Mutations in many synMuv B genes, including lin-35/Rb, also cause somatic...
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