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Article

Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity.

BMC developmental biology - 6 Apr 2007

Ceron Julian, Rual Jean-François, Chandra Abha, Dupuy Denis, Vidal Marc, van den Heuvel Sander

Abstract excerpt

BACKGROUND: The retinoblastoma tumor suppressor (Rb) acts in a conserved pathway that is deregulated in most human cancers. Inactivation of the single Rb-related gene in Caenorhabditis elegans, lin-35, has only limited effects on viability and fertility, yet causes changes in cell-fate and cell-cycle regulation when combined with inactivation of specific other genes. For instance, lin-35 Rb is a synthetic...

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Identifiers

PMID: 17417969
DOI: 10.1186/1471-213X-7-30
PMCID: PMC1863419

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Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity.PMID 17417969Read ↗

Loss of LIN-35, the Caenorhabditis elegans ortholog of the tumor suppressor p105Rb, results in enhanced RNA interference.Semantic proximity Read ↗

Repression of germline RNAi pathways in somatic cells by retinoblastoma pathway chromatin complexes.Semantic proximity Read ↗

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lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48.Semantic proximity Read ↗

Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex.Semantic proximity Read ↗

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