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Article

A Forward Genetic Screen for Suppressors of Somatic P Granules in Caenorhabditis elegans.

G3 (Bethesda, Md.) - 22 Jun 2015

Kelly Ashley L, Senter-Zapata Michael J, Campbell Anne C, Lust Hannah E, Theriault Monique E, Andralojc Karolina M, Updike Dustin L

Abstract excerpt

In Caenorhabditis elegans, germline expression programs are actively repressed in somatic tissue by components of the synMuv (synthetic multi-vulva) B chromatin remodeling complex, which include homologs of tumor suppressors Retinoblastoma (Rb/LIN-35) and Malignant Brain Tumor (MBT/LIN-61). However, the full scope of pathways that suppress germline expression in the soma is unknown. To address this, we performed...

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Identifiers

PMID: 26100681
DOI: 10.1534/g3.115.019257
PMCID: PMC4593002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A Forward Genetic Screen for Suppressors of Somatic P Granules in Caenorhabditis elegans.PMID 26100681Read ↗

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Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity.Semantic proximity Read ↗

Diverse chromatin remodeling genes antagonize the Rb-involved SynMuv pathways in C. elegans.Semantic proximity Read ↗

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