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Article

Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants.

Nature - 28 Jul 2005

Wang Duo, Kennedy Scott, Conte Darryl, Kim John K, Gabel Harrison W, Kamath Ravi S, Mello Craig C, Ruvkun Gary

Abstract excerpt

Caenorhabditis elegans homologues of the retinoblastoma (Rb) tumour suppressor complex specify cell lineage during development. Here we show that mutations in Rb pathway components enhance RNA interference (RNAi) and cause somatic cells to express genes and elaborate perinuclear structures normally limited to germline-specific P granules. Furthermore, particular gene inactivations that disrupt RNAi reverse the...

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PMID: 16049496
DOI: 10.1038/nature04010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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