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Article

Diverse chromatin remodeling genes antagonize the Rb-involved SynMuv pathways in C. elegans.

PLoS genetics - 1 May 2006

Cui Mingxue, Kim E Bridget, Han Min

Abstract excerpt

In Caenorhabditis elegans, vulval cell-fate specification involves the activities of multiple signal transduction and regulatory pathways that include a receptor tyrosine kinase/Ras/mitogen-activated protein kinase pathway and synthetic multivulva (SynMuv) pathways. Many genes in the SynMuv pathways encode transcription factors including the homologs of mammalian Rb, E2F, and components of the...

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Identifiers

PMID: 16710447
DOI: 10.1371/journal.pgen.0020074
PMCID: PMC1463046

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Diverse chromatin remodeling genes antagonize the Rb-involved SynMuv pathways in C. elegans.PMID 16710447Read ↗

C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates.Semantic proximity Read ↗

Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex.Semantic proximity Read ↗

Identification and classification of genes that act antagonistically to let-60 Ras signaling in Caenorhabditis elegans vulval development.Semantic proximity Read ↗

A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling.Semantic proximity Read ↗

LIN-61, one of two Caenorhabditis elegans malignant-brain-tumor-repeat-containing proteins, acts with the DRM and NuRD-like protein complexes in vulval development but not in certain other biological processes.Semantic proximity Read ↗

Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity.Semantic proximity Read ↗

SUMV-1 antagonizes the activity of synthetic multivulva genes in Caenorhabditis elegans.Semantic proximity Read ↗

Loss of LIN-35, the Caenorhabditis elegans ortholog of the tumor suppressor p105Rb, results in enhanced RNA interference.Semantic proximity Read ↗

Multiple levels of redundant processes inhibit Caenorhabditis elegans vulval cell fates.Semantic proximity Read ↗

Repression of germline RNAi pathways in somatic cells by retinoblastoma pathway chromatin complexes.Semantic proximity Read ↗

dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development.Semantic proximity Read ↗

Caenorhabditis elegans lin-13, a member of the LIN-35 Rb class of genes involved in vulval development, encodes a protein with zinc fingers and an LXCXE motif.Semantic proximity Read ↗

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