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Article

USF binding sequences from the HS4 insulator element impose early replication timing on a vertebrate replicator.

PLoS biology - 1 Jan 2012

Hassan-Zadeh Vahideh, Chilaka Sabarinadh, Cadoret Jean-Charles, Ma Meiji Kit-Wan, Boggetto Nicole, West Adam G, Prioleau Marie-Noëlle

Abstract excerpt

The nuclear genomes of vertebrates show a highly organized program of DNA replication where GC-rich isochores are replicated early in S-phase, while AT-rich isochores are late replicating. GC-rich regions are gene dense and are enriched for active transcription, suggesting a connection between ge...

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Identifiers

PMID: 22412349
DOI: 10.1371/journal.pbio.1001277
PMCID: PMC3295818

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22412349-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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