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Article

Thermodynamic and kinetic analysis of an RNA kissing interaction and its resolution into an extended duplex.

Biophysical journal - 7 Mar 2012

Salim Nilshad, Lamichhane Rajan, Zhao Rui, Banerjee Tuhina, Philip Jane, Rueda David, Feig Andrew L

Abstract excerpt

Kissing hairpin interactions form when the loop residues of two hairpins have Watson-Crick complementarity. In a unimolecular context, kissing interactions are important for tertiary folding and pseudoknot formation, whereas in a bimolecular context, they provide a basis for molecular recognition. In some cases, kissing complexes can be a prelude to strand displacement reactions where the two hairpins resolve to...

Topics

Base Sequence
Calorimetry
Fluorescence Resonance Energy Transfer
Inverted Repeat Sequences
Kinetics
Mutation
RNA, Double-Stranded
Thermodynamics

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 22404932
DOI: 10.1016/j.bpj.2011.12.052
PMCID: PMC3296049

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