Article
Unusual mechanical stability of a minimal RNA kissing complex.
Proceedings of the National Academy of Sciences of the United States of America - 24 Oct 2006
Li Pan T X, Bustamante Carlos, Tinoco Ignacio
Abstract excerpt
By using optical tweezers, we have investigated the mechanical unfolding of a minimal kissing complex with only two G.C base pairs. The loop-loop interaction is exceptionally stable; it is disrupted at forces ranging from 7 to 30 pN, as compared with 14-20 pN for unfolding hairpins of 7 and 11 bp. By monitoring unfolding/folding trajectories of single molecules, we resolved the intermediates, measured their rate...
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