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Article

Single-molecule fluorescence resonance energy transfer assays reveal heterogeneous folding ensembles in a simple RNA stem-loop.

Journal of molecular biology - 5 Dec 2008

Gell Christopher, Sabir Tara, Westwood Jonathan, Rashid Abdul, Smith D Alastair M, Harris Sarah-Anne, Stockley Peter G

Abstract excerpt

We have examined the folding ensembles present in solution for a series of RNA oligonucleotides that encompass the replicase translational operator stem-loop of the RNA bacteriophage MS2. Single-molecule (SM) fluorescence assays suggest that these RNAs exist in solution as ensembles of differentially base-paired/base-stacked states at equilibrium. There are two distinct ensembles for the wild-type sequence,...

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Identifiers

PMID: 18805425
DOI: 10.1016/j.jmb.2008.08.088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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